Animations geared towards older audiences are able to use cosmetics in different ways from animations made for children.
Makeup looks among characters may be varied and obvious, but never a topic discussed in the show itself. Makeup may be a way to illustrate how shallow a male character is, or how a female character is valued only for her looks.
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Heavy makeup is more readily seen as a "slutty" characteristic, as opposed to the "evil" interpretation from children's movies... Or are they meant to be the same thing?

2011-Present, Multiple Episodes Tammy is a "Mean Girls" type at Tina Belcher's school. She wears heavy makeup and bleaches her hair. She often pushes Tina to misbehave or act out of character.

2011-Present, Season 2, Episode 8 Tammy bullies Tina into wearing makeup, and true to her character, Tina is awkward and unsure about it. Tina is easily influenced and often just wants to fit in and make friends, but usually returns to her true self.

This is one of the only accurate portrayals of mascara in animated media, with the added bonus that it doesn't reflect negatively on the character's morality or serve to make her scary to children.

2011- Present, Season 1, Episode 6 Some of the heavy makeup in the series is seen on a group of drag queens. This perpetuates the idea of makeup as a mask or costume, but also sheds a positive light on how makeup can be used for the self expression of a character. The queens are accepted by other characters and attend Tina's birthday party.

1997-2010, Episode 216 Bobby is drafted into the Powder Puff Boys, a cheer team for the female powder puff football team. His father gets excited and drives him to participate, but when it comes to light the boys are dressing up so the football team can make fun of them, the parents protest and the group is shut down.

Bobby often says or does things not traditionally "male," and his father will say, "there's something not right about that boy."

2005- Present, Multiple Episodes Rodger is an alien living on Earth with the Smith family and frequently cross-dresses for fun or to deceive people. Other characters sometimes accept his choices or make derogatory remarks about his sexuality.

"American Dad," 2005-Present, Season 6, Episode 5 When Stan lets it slip he married Francine for her looks, Francine "lets herself go," as a test of Stan's loyalty. They eventually go crazy trying to keep the marriage working as they allow themselves to get more and more unattractive, and end up going back to their conventional ways.

Francine supposedly goes from the previous image, to this, in two weeks. Her hair is messy and her roots are growing in, her eyebrows grew together into a unibrow, she has a mustache, she's gained weight, and not wearing makeup, apparent in the dulled lip color and lines under her eyes. This helps to illustrate the immense amount of work and money that goes into keeping up appearances.

1999- Present, Season 4, Episode 3 When her husband goes blind, Lois stops wearing makeup. When the dog, Brian, asks if she stopped wearing makeup, she says how nice it's been to not worry about it. Brian then asks, "Are- are you sure you have the skin for that?" This scene is especially problematic because it perpetuates the idea that women wear makeup for people other than themselves, and that men have an expectation for women to look the way men want them to look.

1997- Present, Season 7, Episode 14 Lexus is a waitress at a restaurant meant to parody the Hooters chain... but with pre-teen girls. Yes, really. Lexus is later revealed to be an escort of sorts, that was only using the main character for money while he thought they were in a legitimate relationship together. Her heavy makeup is supposed to make her look slutty and/or trashy.

1989- Present, Episode 205 Marge's husband invents a makeup gun to help women get ready faster in the morning. He accidentally uses "whore mode" on Marge, painting her face in heavy and exaggerated makeup. When the daughter, Lisa, says women won't like the invention, Homer replies with "Women will like what I tell them to like!"

2005- Present, Season 1, Episode 3 Cristal is a prostitute that poses as a main character's girlfriend for money. In a show that features few female characters, she wears very obvious makeup. This perpetuates the interpretation of makeup as "slutty."

Various appearances in shorts from the 1930's to the present Betty Boop is a sexual icon and represents the carefree nature of the roaring 20's. Vintage cartoons usually occur misogynistic and politically incorrect by today's standards. Her big eyes and red lips follow the standards for female protagonists.

1999-2013 This is a nice representation of putting on real lipstick. Lips are usually a light, dull pink, and lipstick can darken and define them. Seeing a character apply makeup in an almost real way is a nice change from how most characters magically have red lips no matter what.

2009- Present, multiple episodes The women of "Archer" all wear some form of makeup, even when they are just waking up, swimming, or in the middle of a gun fight. The facial proportions stay a little more realistic to real life, but the mechanics of cosmetics are still neglected.

2009- Present, Multiple episodes Katya's character undergoes many changes. She's a villain at first, tasked with killing the main character. Later she becomes the main character's love interest and fiancee. She recurs off and on, usually on good terms. Her makeup is understated from the normal "ambiguous," character look, and more realistic for a professional woman.

2009- Present, Multiple Episodes Malory is one of the few instances of light makeup being used on an older character. Age is often seen as a negative in children's shows, and older characters try to cover up or change their appearance with heavy makeup. Malory's look is sophisticated and professional, as fits her status in the agency she runs.